Fragile Treg cells: Traitors in immune homeostasis?

Fragile Treg cells: Traitors in immune homeostasis?

Blog Article

Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis.However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression.Fragile Treg cells are formatively, phenotypically and functionally diverse in Bandana Top various diseases, further complicating the role of Treg cells in the immunotherapeutic response and offering novel targets for disease treatment by modulating specific Treg subsets.In this review, we summarize findings on fragile Treg cells to provide a framework for characterizing the formation and role of fragile Treg cells in different diseases, and we discuss how this information Hot Water System Element may guide the development of more specific Treg-targeted immunotherapies.